Tricorder technology advances with nanoscale discovery

Applications for the miniaturised, handheld devices include medical testing, explosives detection and food safety.

Researchers found that when paper used to collect a sample was coated with carbon nanotubes, the voltage required was 1,000 times reduced, the signal was sharpened and the equipment was able to capture far more delicate molecules.

A team of researchers from Purdue University in the US and the Indian Institute of Technology Madras performed the study, which is detailed in Angewandte Chemie.

‘This is a big step in our efforts to create miniature, handheld mass spectrometers for the field,’ said R. Graham Cooks, Purdue’s Henry B. Hass Distinguished Professor of Chemistry. ‘The dramatic decrease in power required means a reduction in battery size and cost to perform the experiments. The entire system is becoming lighter and cheaper, which brings it that much closer to being viable for easy, widespread use.’

Cooks and Thalappil Pradeep, a professor of chemistry at the Indian Institute of Technology Madras, Chennai, led the research.

‘Mass spectrometry is a fantastic tool, but it is not yet on every physician’s table or in the pocket of agricultural inspectors and security guards,’ Pradeep said in a statement. ‘Great techniques have been developed, but we need to hone them into tools that are affordable, can be efficiently manufactured and easily used.’

The US National Science Foundation-funded study used an analysis technique developed by Cooks and his colleagues called PaperSpray ionisation. The technique relies on a sample obtained by wiping an object or placing a drop of liquid on paper wet with a solvent to capture residues from the object’s surface. A small triangle is then cut from the paper and placed on an attachment of the mass spectrometer where voltage is applied. The voltage creates an electric field that turns the mixture of solvent and residues into fine droplets containing ionised molecules that enter the mass spectrometer for analysis. The mass spectrometer then identifies the sample’s ionised molecules by their mass.

The technique depends on a strong electric field and the nanotubes act like antennas that create a strong electric field from a very small voltage. One volt over a few nanometres creates an electric field equivalent to 10 million volts over a centimetre, Pradeep said.

‘The trick was to isolate these tiny, nanoscale antennae and keep them from bundling together because individual nanotubes must project out of the paper,’ he said. ‘The carbon nanotubes work well and can be dispersed in water and applied on suitable substrates.’

In addition to reducing the size of the battery required and energy cost to run the tests, the new technique also simplified the analysis by nearly eliminating background noise, Cooks said.

‘Under these conditions, the analysis is nearly noise free and a sharp, clear signal of the sample is delivered,’ he said. ‘We don’t know why this is – why background molecules that surround us in the air or from within the equipment aren’t being ionised and entering into the analysis. It’s a puzzling, but pleasant surprise.’

The reduced voltage required also makes the method gentler than the standard PaperSpray ionization techniques.

‘It is a very soft method,’ Cooks said. ‘Fragile molecules and complexes are able to hold together here when they otherwise wouldn’t. This could lead to other potential applications.’

The team plans to investigate the mechanisms behind the reduction in background noise and potential applications of the gentle method, but the most promising aspect of the new technique is its potential to miniaturize the mass spectrometry system, Cooks said.