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The feat marks the first time that DNA has been used to direct the assembly and growth of complex nanowires.
The tiny new structures can create and detect light and, with mechanical pressure, generate electricity. The wires’ optical and electrical properties would allow for a range of applications, from medical diagnostics and security sensors to fibre optical networks and computer circuits.
‘The use of DNA to assemble nanomaterials is one of the first steps toward using biological molecules as a manufacturing tool,’ said Adam Lazareck, a graduate student in Brown’s Division of Engineering. ‘If you want to make something, turn to Mother Nature. From skin to sea shells, remarkable structures are engineered using DNA.’
Lazareck, who works in the laboratory Jimmy Xu, professor of engineering and physics, led the research. The work is an example of “bottom up” nanoengineering. Instead of moulding or etching materials into smaller components, such as computer circuits, engineers are experimenting with ways to get biological molecules to do their own assembly work. Under the right chemical conditions, molecular design and machinery – such as light-sensing proteins or viral motors – can be used to create miniscule devices and materials.
In this work, the team of engineers and scientists took the “bottom-up” approach one step further by successfully harnessing DNA to provide instructions for this self-assembly. The new structures created in the Xu lab are the first example of DNA-directed self-assembly and synthesis in nanomaterials.
The Xu lab is the first in the world to make uniform arrays of carbon nanotubes. Lazareck and his collaborators at Brown and
This synthetic snippet of DNA carries a sequence of 15 “letters” of genetic code. It was chosen because it attracts only one complement – another sequence made up of a different string of 15 “letters” of genetic code. This second sequence was coupled with a gold nanoparticle, which acted as a chemical delivery system of sorts, bringing the complementary sequences of DNA together. To make the wires, the team put the arrays in a furnace set at 600° C and added zinc arsenide. The result was Zinc oxide wires measuring about 100-200 nanometres in length.
The team conducted control experiments – introducing gold nanoparticles into the array with no DNA attached or using nanotubes with no DNA at the tips in the nanotube array – and found that very few DNA sequences stuck. And no wires could be made. Lazareck said the key is DNA hybridization, the process of bringing single, complimentary strands of DNA together to reform the double helices that DNA is famous for.
‘DNA provides an unparalleled instruction manual because it is so specific,’ Lazareck said. ‘Strands of DNA only join together with their complements. So with this biological specificity, you get manufacturing precision. The functional materials that result have attractive properties that can be applied in many ways.’
Five ways to prepare for your first day
If I may add my own personal Tip No. 6 it goes something like this: From time to time a more senior member of staff will start explaining something...